Annual advances of acupuncture research in 2022

This article reviews the major advances in acupuncture research in 2022, including clinical reports, basic research, and reviews. In terms of the type of literature, most of them are systematic reviews and clinical trials, while high-quality basic studies can also be found. The innovative inventions and researches in this field are of increasing quality and in a wide range of fields, acupuncture is attracting more and more attention in the international arena. In particular, some acupuncture combined sensors such as H2 -EC/SD co-therapy, precise positioning, and vivo monitoring of neurotransmitter has been used for oncological diseases and neuropathic pain. Acupuncture has been shown to be beneficial in the treatment of pain, stroke, psychiatric disorders, cancer, COVID-19 and others. Most of the studies show that acupuncture can play a positive role in various diseases and provide evidence for clinical applications and mechanism research.Copyright © 2023 By Author(s). Published by TMR Publishing Group Limited.

A reflection on the Great Resignation in the hospitality and tourism industry

Purpose: This paper aims to provide a critical reflection on the Great Resignation in the hospitality and tourism industry in the wake of the COVID-19 pandemic. Specifically, this paper reviews the causes and effects of the Great Resignation, addresses the labor shortage in this industry and proposes strategies that can help manage the challenges. Design/methodology/approach: This paper is based on a critical analysis of emerging phenomena, related literature and researchers' experiences and insights. Findings: The Great Resignation has presented unprecedented challenges for the hospitality and tourism industry. A closer examination reveals that the pandemic has served as a catalyst rather than a leading cause of this trend. Workforce issues are becoming increasingly complex under contemporary influences, including internal elements such as new explications at work and external factors like the gig economy and technology implementation. Practical implications: This study provides practical implications on how Hospitality and Tourism practitioners can respond to the Great Resignation on micro, meso and macro levels. The practical implications revolve around employees' changing needs and preferences in the wave of Great Resignation, as well as the necessity for employers' reflection and improvement. Originality/value: This study marks an initial attempt to provide a critical assessment of a contemporary issue involving the Great Resignation. This paper extends its discussion through an advanced analysis of the issue, offers suggestions to manage current obstacles related to labor issues in hospitality and tourism, and illuminates future research directions. © 2022, Emerald Publishing Limited.

Impact of COVID-19 Pandemic on Urological Service: Experience at a Taiwanese Tertiary Center

Purpose: The Taiwan Central Epidemic Command Center raised the coronavirus disease 2019 (COVID-19) pandemic alert to level 3 throughout the nation since May 19, 2021, and asked hospitals to reduce patient intake. Surgical departments were the worst affected. The aim of this study is to share experiences of urological practice adjustment in a tertiary medical center during the pandemic and to evaluate the impact of the COVID-19 pandemic on the urological service in Taiwan under a level 3 epidemic alert. Materials and Methods: This observational study was conducted from June 1, 2021, to June 31, 2021, when a level 3 pandemic alert was declared. Data of patients visiting the urology department at the Taipei Veterans General Hospital were recorded and compared with data 1 year before the COVID-19 outbreak in Taiwan (June 1, 2020, to June 31, 2020). Data included outpatient visits, elective surgeries, emergent surgeries, functional urological examinations, and diagnostic procedures in outpatient settings. Results: There was no significant decrease in all types of uro-oncological surgeries, except bladder urothelial carcinoma (UCB)-related procedures. The total number of UCB-related procedures showed 66.67% reduction. Stone-related surgeries were reduced by 45.7%. Only 12% of all transurethral prostate resections were performed in the pandemic. There was a significant decrease in all types of functional urology and andrology procedures. More than 30% reduction was noted in the number of patients visiting the urology department in June 2021 compared to that in June 2020. Conclusion: Our data provide a reference of how the urological service was affected during the level 3 pandemic alert in Taiwan. We postponed most elective surgeries and outpatient visits or diagnostic outpatient examinations procedures according to prioritization guidelines. Uro-oncology-related service was less affected because oncology patients have a stronger motivation for treatment. Benign urological condition-related procedures were significantly influenced. After the epidemic slowdown, the backlog should be gradually managed based on priority.

A reflection on the Great Resignation in the hospitality and tourism industry

Purpose: This paper aims to provide a critical reflection on the Great Resignation in the hospitality and tourism industry in the wake of the COVID-19 pandemic. Specifically, this paper reviews the causes and effects of the Great Resignation, addresses the labor shortage in this industry and proposes strategies that can help manage the challenges. Design/methodology/approach: This paper is based on a critical analysis of emerging phenomena, related literature and researchers’ experiences and insights. Findings: The Great Resignation has presented unprecedented challenges for the hospitality and tourism industry. A closer examination reveals that the pandemic has served as a catalyst rather than a leading cause of this trend. Workforce issues are becoming increasingly complex under contemporary influences, including internal elements such as new explications at work and external factors like the gig economy and technology implementation. Practical implications: This study provides practical implications on how Hospitality and Tourism practitioners can respond to the Great Resignation on micro, meso and macro levels. The practical implications revolve around employees’ changing needs and preferences in the wave of Great Resignation, as well as the necessity for employers’ reflection and improvement. Originality/value: This study marks an initial attempt to provide a critical assessment of a contemporary issue involving the Great Resignation. This paper extends its discussion through an advanced analysis of the issue, offers suggestions to manage current obstacles related to labor issues in hospitality and tourism, and illuminates future research directions. © 2022, Emerald Publishing Limited.

The Effectiveness of Extended Parallel Process Model on COVID-19 Health Promotion and Social Media Sharing Willingness

This study aimed to evaluate the effectiveness of the COVID-19 health promotion poster using the Extended Parallel Process Model (EPPM) and discuss the relationship between the willingness to repost the poster by applying EPPM within the design process. Based on past studies, emotionally appealing posters that incorporate EPPM may influence viewers' health behavior, but few studies adopt the model to investigate the impact on social media sharing behavior. To discover whether EPPM is applicable to sharing the information on Instagram, eight young adults who are constantly using Instagram were interviewed to collect their opinions on comparing the two self-design COVID-19 health promotion posters. We found out that EPPM is workable on increasing COVID-19 health awareness for individuals;however, the result revealed that EPPM did not positively affect Instagram sharing willingness. Thus, although COVID-19 health promotion is essential in increasing public health awareness, most participants still preferred to share interesting information, cartoonish pictures, or personalized messages on their personal Instagram. The results can further be utilized as a reference on future Instagram health poster design and other social media applications about health posters and information sharing. © 2022 ACM.

MEASURING THE IMPACT OF ECONOMIC POLICIES ON CO2 EMISSIONS: WAYS TO ACHIEVE GREEN ECONOMIC RECOVERY IN THE POST-COVID-19 ERA

Regional attempts to reduce pollution levels emerging from the European Union (EU) relative to 2010 are contrasted with unique policies of individual member countries' aims to achieve a 10% reduction per country. Given this scenario, this research expands on the topic by developing a novel framework that links macroeconomic policies, total national expenditure per person, traditional energy use, renewable energy use, and CO2 emissions levels in EU countries from 1990 to 2016. The study utilizes the second generation cross-sectional-autoregressive-distributed lag (CS-ARDL) panel data method. According to the study's findings, the monetary instruments of growth exacerbated the adverse effects of CO2 emissions, and by tightening monetary policy, the harmful effects of CO2 emissions levels have been reduced. Further, the Granger causality test indicates a bidirectional causality between monetary policy and CO2 emissions levels, and unidirectional causality from the policy assessment for energy use. The finding confirms that the assessment policy recommendations on energy consumption have future effects on ecological value.

Synthesis and evaluation of N-cycloberberine derivatives as a novel class of anti-SARS-CoV-2 pseudovirus agents

There is no specific drug against COVID-19, but berberine (BBR) has moderate anti-SARS-CoV-2 pseudovirus activity. Taking BBR as the lead, 18 novel N-cycloberberine derivatives were synthesized and evaluated for their anti-SARS-CoV-2 pseudovirus activities in vitro. Structure-activity relationship analysis revealed that introducing an appropriate heterocyclic group at position 9 might be beneficial for potency. Among the tested compounds, compound 3m showed the most potent activity against SARS-CoV-2, with EC50 value of 1.61 μmol·L-1 and SI value of 22.2, much better than that of BBR. Additional experiment indicated that 3m had inhibitory activity on multiple processes in viral invasion, including adsorption and membrane fusion, suggesting a multi-target synergistic mechanism of action. These results provide a novel family of lead compounds for the discovery of anti-SARS-CoV-2 candidates. © 2021, Chinese Pharmaceutical Association. All rights reserved.

Results and Discussion on National Vaccine Proficiency Testing Schemes in 2020

OBJECTIVE: To acquire the knowledge of quality control performance through carrying out proficiency Testing Schemes (PTS) nationwide. METHODS: National Institutes for Food and Drug Control(NIFDC) schemed three PTS to evaluate the testing competence of participants from the aspects of safety and stability of vaccine products and pseudotyped virus-based neutralization assay, pseudotyped virus based neutralization assay(PBNA), which takes as a hand of COVID-19 vaccine development. RESULTS: Eighty-nine participants took part in the three PTS and the satisfaction rate stated as 96.9%, 96.4% and 76.0%. CONCLUSION: The testing ability and quality control performance of Official Medical Control Laboratories (OMCL), manufacturers and research institutes are acceptable. The testing results of sterile testing and aluminum assay of aluminum adjuvanted vaccine can be assured well, while the ability of PBNA needs to be improved by some manufacturers.

Association between serum amyloid A levels and predicting disase severity in COVID-19 patients: a systematic review and meta-analysis.

OBJECTIVE: Global health resources have faced huge challenges from the pandemic coronavirus disease 2019 (COVID-19) since December 2019. Numerous clinical reports have focused on the association of serum amyloid A (SAA) levels with severe COVID-19. However, a systematic analysis synthesizing these findings has not been performed. This meta-analysis aims to systematically review the role of SAA levels in distinguishing among patients with mild, severe, and critical COVID-19. MATERIALS AND METHODS: A comprehensive literature search was conducted in the PubMed, Embase, and Web of Science databases from the beginning of the COVID-19 outbreak to February 1, 2021. Two investigators independently reviewed suitable studies. Pooled standardized mean differences (SMDs), 95% confidence intervals (CIs), and correlation coefficients (r) were computed using a random-effects model. RESULTS: We included 19 of 317 titles identified by our search, involving a total of 1806 mild cases and 1529 severe cases. Compared with the mild group, the severe group had markedly higher SAA levels (SMD=1.155, 95% CI 0.89, 1.42). Subgroup analysis revealed that the SAA level differences between the severe group and the mild group were associated with age, sample size, and detection method. Sensitivity analyses showed the credibility and robustness of our results. In addition, in six studies involving 1144 patients with severe COVID-19 and 433 patients with critical COVID-19, SAA was significantly higher in patients with critical COVID-19 (SMD=0.476, 95% CI 0.13, 0.82). CONCLUSIONS: High circulating SAA levels were markedly associated with COVID-19 severity, especially for subjects aged less than 50 years, compared with patients with mild COVID-19. SAA concentrations were also significantly higher in patients with critical COVID-19 compared with those with severe COVID-19. Further studies in large cohorts are needed to confirm whether the SAA is a useful tool in discriminating among patients with stable COVID-19, those with acute exacerbations, and subjects without disease.

Immunogenicity and safety of a SARS-CoV-2 inactivated vaccine in healthy adults: randomized, double-blind, and placebo-controlled phase 1 and phase 2 clinical trials

BACKGROUND: The significant morbidity and mortality resulted from the infection of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) call for urgent development of effective and safe vaccines. We report the immunogenicity and safety of an inactivated SARS-CoV-2 vaccine, KCONVAC, in healthy adults. METHODS: Phase 1 and phase 2 randomized, double-blind, and placebo-controlled trials of KCONVAC were conducted in healthy Chinese adults aged 18-59 years. The participants in the phase 1 trial were randomized to receive two doses, one each on Days 0 and 14, of either KCONVAC (5 mug/dose or 10 mug/dose) or placebo. The participants in the phase 2 trial were randomized to receive either KCONVAC (at 5 or 10 mug/dose) or placebo on Days 0 and 14 (0/14 regimen) or Days 0 and 28 (0/28 regimen). In the phase 1 trial, the primary safety endpoint was the proportion of participants experiencing adverse reactions/events within 28 days following the administration of each dose. In the phase 2 trial, the primary immunogenicity endpoints were neutralization antibody seroconversion and titer and anti-receptor-binding domain immunoglobulin G seroconversion at 28 days after the second dose. RESULTS: In the phase 1 trial, 60 participants were enrolled and received at least one dose of 5-mug vaccine (n = 24), 10-mug vaccine (n = 24), or placebo (n = 12). In the phase 2 trial, 500 participants were enrolled and received at least one dose of 5-mug vaccine (n = 100 for 0/14 or 0/28 regimens), 10-mug vaccine (n = 100 for each regimen), or placebo (n = 50 for each regimen). In the phase 1 trial, 13 (54%), 11 (46%), and 7 (58%) participants reported at least one adverse event (AE) after receiving 5-mug vaccine, 10-mug vaccine, or placebo, respectively. In the phase 2 trial, 16 (16%), 19 (19%), and 9 (18%) 0/14-regimen participants reported at least one AE after receiving 5-mug vaccine, 10-mug vaccine, or placebo, respectively. Similar AE incidences were observed in the three 0/28-regimen treatment groups. No AEs with an intensity of grade 3+ were reported, expect for one vaccine-unrelated serious AE (foot fracture) reported in the phase 1 trial. KCONVAC induced significant antibody responses;0/28 regimen showed a higher immune responses than that did 0/14 regimen after receiving two vaccine doses. CONCLUSIONS: Both doses of KCONVAC are well tolerated and able to induce robust immune responses in healthy adults. These results support testing 5-mug vaccine in the 0/28 regimen in an upcoming phase 3 efficacy trial. TRIAL REGISTRATION: http://www.chictr.org.cn/index.aspx (No. ChiCTR2000038804, http://www.chictr.org.cn/showproj.aspx?proj=62350;No. ChiCTR2000039462, http://www.chictr.org.cn/showproj.aspx?proj=63353).